5-CHLORO-8-QUINOLINETRIFLUOROMETHANESUL& synthesis
- Product Name:5-CHLORO-8-QUINOLINETRIFLUOROMETHANESUL&
- CAS Number:157437-38-2
- Molecular formula:C10H5ClF3NO3S
- Molecular Weight:311.66
Yield:157437-38-2 90.2%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 12 h;
Steps:
1.1 Step (1), Preparation of Intermediate A.
179 g (1 mol) of 5-chloro-8-hydroxyquinoline was weighed successively,282 g (1 mol) of trifluoromethanesulfonic anhydride,1500 g of dichloromethane,150 g (1.5 mol) of triethylamine in 2 L three-necked flask,Room temperature stirring 12h,To the reaction system was added 500 g of water,Dispensing,Organic phase with 500g of water, washed three times, spin dry,Using a petroleum ether: ethyl acetate = 4: 1 column to afford 280.6 g of the product A,Yield 90.2%Product purity GC was 99.5%.
References:
CN105924395,2016,A Location in patent:Paragraph 0074; 0075; 0076; 0077
130-16-5
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157437-38-2
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