6-(3-ETHOXY-PHENYL)-1,3-DIHYDRO-INDOL-2-ONE synthesis

6synthesis methods

Product Name:6-(3-ETHOXY-PHENYL)-1,3-DIHYDRO-INDOL-2-ONE
CAS Number:215433-92-4
Molecular formula:C16H15NO2
Molecular Weight:253.3

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3'-ETHOXY-3-NITRO-BIPHENYL-4-ACETIC ACID

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6-(3-ETHOXY-PHENYL)-1,3-DIHYDRO-INDOL-2-ONE

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Yield:215433-92-4 91%

Reaction Conditions:

in acetic acid;

Steps:

6-(3-Ethoxyphenyl)-2-oxindole

Iron powder (2.4 g) was added in one portion to 4.6 g of 3'-ethoxy-3-nitrobiphenyl-4-acetic acid in 40 mL of glacial acetic acid and refluxed for 2 hours. The reaction mixture was concentrated to dryness, treated repeatedly with ethyl acetate and filtered to remove the insolubles. The filtrate was washed twice with 1N hydrochloric acid and brine and then dried over anhydrous sodium sulfate and concentrated to give 3.5 g (91% yield) of 6-(3-ethoxyphenyl)-2-oxindole as a light brown solid.

References:

US2003/69421,2003,A1

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References

364-73-8 Synthesis