ChemicalBook CAS DataBase List 6-AMINOISOQUINOLINE

6-AMINOISOQUINOLINE synthesis

8synthesis methods

Product Name:6-AMINOISOQUINOLINE
CAS Number:23687-26-5
Molecular formula:C9H8N2
Molecular Weight:144.17

34784-05-9 Synthesis

34784-05-9
319 suppliers
$5.00/1g

23687-26-5
204 suppliers
$16.00/100mg

Yield:23687-26-5 85%

Reaction Conditions:

with ammonium hydroxide;copper(ll) sulfate pentahydrate in water at 190; for 6 h;

Steps:

1 1
Reference Example 1 Synthesis of 6-aminoisoquinoline (Reference Compound 1) 6-bromoisoquinoline that weighed 17.2 g (see WO 2008/077553), 200 mL of 28% ammonia water and 10.8 g of copper (II) sulfate pentahydrate were put into the autoclave and tightly sealed, and the mixture was then stirred at 190° C. for 6 hours. After cooling to room temperature, the reaction solution was poured into 250 mL of a 10% aqueous sodium hydroxide solution, followed by extraction with ethyl acetate (100 mL*5). The extract was dried over anhydrous sodium sulfate, filtered, and then concentrated. The obtained crude product was suspended in dichloromethane and then filtered to obtain 10.2 g of the compound of interest as a light brown crystal (85%). ¹H-NMR spectrum (CDCl₃, δ ppm): 5.54 (br s, 2H), 6.58 (s, 1H), 7.00 (d, J=9.0 Hz, 1H), 7.35 (d, J=5.5 Hz, 1H), 7.75 (d, J=9.0 Hz, 1H), 8.32 (d, J=5.5 Hz, 1H), 8.98 (s, 1H)

References:

D. WESTERN THERAPEUTICS INSTITUTE, INC US2012/35159, 2012, A1 Location in patent:Page/Page column 8

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70538-57-7 Synthesis