6-Azauracil synthesis
- Product Name:6-Azauracil
- CAS Number:461-89-2
- Molecular formula:C3H3N3O2
- Molecular Weight:113.07
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461-89-2
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Yield:461-89-2 61.6%
Reaction Conditions:
with sodium hydroxide in methanol;1,2-dimethoxyethane at 80; for 24 h;
Steps:
2.2 (2) Synthesis of 6-azauracil (CD-2)
Weigh 2-[2-(aminocarbonyl) fluorenylene]33.9 g (0.259 mol) and sodium hydroxide 51 g (1.275 mol)Soluble in 150mlIn ethylene glycol,The mixture was stirred under magnetic stirring at 80 ° C for 12 h.After cooling by cooling water,Add 250ml of methanol,Allow to stand for 12h,After suction filtration,Solvent recovery,41.9 g of wet product were obtained,Dissolved in 60ml of water,Adjust pH to pH <3 with hydrochloric acid,Then heated to 80 ° C, After stirring for half an hour,Cool down to 10 ° C with ice brine.After suction filtration and rinsing with ultrapure water,Vacuum drying gave 6-aza-uracil (CD-2) 18 g (0.159 mol, yield: 61.6%).
References:
Central South University;Zhong Shian;Peng Wei;Chen Jian;Liu Hui;Li Xiufang;Li Jianbing;Tang Rongdi CN108440505, 2018, A Location in patent:Paragraph 0089; 0102; 0103; 0104
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461-89-2
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