6-BROMO-2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID synthesis
- Product Name:6-BROMO-2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID
- CAS Number:5109-98-8
- Molecular formula:C15H9BrN2O2
- Molecular Weight:329.15
1122-62-9
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87-48-9
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$10.00/5g
5109-98-8
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$57.50/250 mg
Yield:-
Reaction Conditions:
in aqueous KOH;ethanol
Steps:
26 6-Bromo-2-(2-pyridinyl)quinoline-4-carboxylic acid
Preparation 26 6-Bromo-2-(2-pyridinyl)quinoline-4-carboxylic acid To a suspension of 5-bromo isatin (5 g, 20.5 mmol) and 2-acetylpyridine (2.5 g, 20.5 mmol) in aqueous KOH (1.2 g, 33%) was added EtOH until a solution formed. The mixture was refluxed over night. The reaction mixture was neutralized with HOAc (50%) and filtered. The solid was resuspended in EtOH and filtered to give the title compound (5.5 g). LC: 1.66 and MH+: 329.
References:
Bi, Yingzhi;Yu, Guixue;Rotella, David P.;Macor, John E. US2002/177587, 2002, A1