6-METHOXY-1 2 3 4-TETRAHYDRO-9H-PYRIDO-& synthesis
- Product Name:6-METHOXY-1 2 3 4-TETRAHYDRO-9H-PYRIDO-&
- CAS Number:17952-63-5
- Molecular formula:C13H14N2O3
- Molecular Weight:246.26
608-07-1
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$13.00/5g
298-12-4
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$5.00/25g
17952-63-5
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$55.00/25mg
Yield:17952-63-5 98%
Reaction Conditions:
with potassium carbonate in water;ethyl acetate at 20; pH=5; for 24 h;Pictet-Spengler Synthesis;
Steps:
General procedure for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-1-carboxylic acids (8).
General procedure: Tryptamines (7a-c, 60 mmol) were suspended in EtOAc (145 mL) and the aqueous solution of glyoxalic acid monohydrate (70 mmol in 70 mL water) was added to the reaction mixture. Then pH was set to 5 with the addition of a 10% aqueous K2CO3 solution and the mixture was stirred at room temperature for 24 h. After the reaction was complete, the mixture was filtered and the solid product was washed with EtOAc and Et2O.
References:
Szabó, Tímea;Hazai, Viktor;Volk, Balázs;Simig, Gyula;Milen, Mátyás [Tetrahedron Letters,2019,vol. 60,# 22,p. 1471 - 1475] Location in patent:supporting information
66-83-1
248 suppliers
$14.14/250mgs:
298-12-4
433 suppliers
$5.00/25g
17952-63-5
23 suppliers
$55.00/25mg