ChemicalBook CAS DataBase List 6-(Trifluoromethyl)nicotinic acid

6-(Trifluoromethyl)nicotinic acid synthesis

4synthesis methods

Product Name:6-(Trifluoromethyl)nicotinic acid
CAS Number:231291-22-8
Molecular formula:C7H4F3NO2
Molecular Weight:191.11

216431-85-5 Synthesis

216431-85-5
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231291-22-8
345 suppliers
$4.00/1g

Yield:231291-22-8 97.3%

Reaction Conditions:

with sulfuric acid;water;acetic acidReflux;

Steps:

5 Example 5

In a 10L three-necked flask was charged water 1420g, sulfuric acid 2440g, glacial acetic acid 150mL slowly added 6- (trifluoromethyl) nicotinonitrile 870g (5mol).Reflux overnight reaction.Cool, add ice and cool with ice-brine to precipitate a white solid.The filtrate was extracted with ethyl acetate. The organic phases were combined, washed twice with water and the organic phase was dried to dryness and acid-washed to give 930 g of 6-(trifluoromethyl)-3-picolinic acid as a beige solid. The yield was 97.3%.

References:

CN107298677,2017,A Location in patent:Paragraph 0036-0038

64-19-7 Synthesis