ChemicalBook CAS DataBase List 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone synthesis

13synthesis methods

Product Name:7,8-Dihydroxyflavone
CAS Number:38183-03-8
Molecular formula:C15H10O4
Molecular Weight:254.24

4H-1-Benzopyran-4-one, 2-phenyl-7,8-bis(phenylmethoxy)-

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Yield:38183-03-8 90.5%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in tetrahydrofuran;methanol at 40; under 4560.31 - 6080.41 Torr;

Steps:

1.6; 2.6; 3.6; 4.6; 5.6; 6.6 (6) Synthesis of compound dhf6

1.3kg dhf-5, 16L methanol: thf=1:1, 270g palladium-carbon were sequentially added into the autoclave, the temperature was controlled to be about 40°C, hydrogen was introduced to control the pressure to react at 6-8 atmospheres, and tlc followed the reaction. After most of the solvent is screwed directly off (part of the methanol and all thf) After completion of the reaction, palladium carbon was removed by suction filtration cooling crystallization, filtration and washed and dried to give yellow-green solid product was 680g. Melting point: 178°C, yield: 90.5%.

References:

CN111303105,2020,A Location in patent:Paragraph 0035-0076