7-Nitroindazole synthesis
- Product Name:7-Nitroindazole
- CAS Number:2942-42-9
- Molecular formula:C7H5N3O2
- Molecular Weight:163.13
570-24-1
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2942-42-9
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Yield:2942-42-9 98%
Reaction Conditions:
with acetic acid;sodium nitrite in water;
Steps:
6.6.14.d
To a stirred solution of step-a-c product (10 g, 0.065 mol) in acetic acid (470 ml, 47 times), a solution of sodium nitrite (1.54 g, 0.06 mol, 1.1 eq) in water (9 ml) was added and the reaction mass was stirred for 30 - 45 min. Progress of the reaction was monitored by TLC (30% ethyl acetate/hexane, Rr-0.7). On completion of the reaction, acetic acid was distilled off and the residue obtained was taken in ice water (200 ml). Solid formed was filtered, washed with cold water and dried to yield the required product as an yellow colored solid (10 g, 98% yield).
References:
WO2010/127855,2010,A1 Location in patent:Page/Page column 124; 125
173459-52-4
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2942-42-9
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5274-70-4
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2942-42-9
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