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1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione synthesis
- Product Name:1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
- CAS Number:830346-47-9
- Molecular formula:C13H10F4N2O2
- Molecular Weight:302.22
![6-Methyluracil](/CAS/GIF/626-48-2.gif)
626-48-2
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![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL BROMIDE](/CAS/GIF/239087-08-2.gif)
239087-08-2
203 suppliers
$14.00/1g
![1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione](/CAS/20180713/GIF/830346-47-9.gif)
830346-47-9
185 suppliers
$24.00/100mg
Yield:830346-47-9 89%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide;potassium carbonate in N,N-dimethyl-formamide at 70; for 18 h;Solvent;Reagent/catalyst;Temperature;
Steps:
1-6 Example 1
In the reactor, 1.0 g, 1.0 equiv. as shown in Formula IV2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene was dissolved in 10 mL of DMF.To this was added 1.2 equiv. 6-methyluracil as shown in Formula V, 1.8 equiv. potassium carbonate,0.1equiv. of TBAI, the system is heated to 70 ° C for 18h;After the reaction was completed, the reaction mixture was concentrated to dryness, and the concentrate was washed with a mixture of dichloromethane and 1N aqueous hydrochloric acid.The organic phase is separated, and the organic phase is washed successively with a saturated aqueous solution of sodium hydrogencarbonate and brine.Subsequently, it is dried over sodium sulfate and spin-dried to obtain 0.89 equiv. of the polysubstituted pyrimidine derivative as shown in Formula I.The yield was 89%.
References:
Anhui Nuoquan Pharmaceutical Co., Ltd.;Liu Haijie;Hu Zhigang;Xu Liangzhi;He Darong;Du Xiaopeng;Qian Zhujin;He Yong CN109761911, 2019, A Location in patent:Paragraph 0024-0037
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674-82-8
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![1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA](/CAS2/GIF/830346-46-8.gif)
830346-46-8
147 suppliers
$24.00/100mg
![1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione](/CAS/20180713/GIF/830346-47-9.gif)
830346-47-9
185 suppliers
$24.00/100mg
![6-Methyluracil](/CAS/GIF/626-48-2.gif)
626-48-2
374 suppliers
$10.00/25 g
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL](/CAS/GIF/152211-15-9.gif)
152211-15-9
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![1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione](/CAS/20180713/GIF/830346-47-9.gif)
830346-47-9
185 suppliers
$24.00/100mg
![1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA](/CAS2/GIF/830346-46-8.gif)
830346-46-8
147 suppliers
$24.00/100mg
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5394-63-8
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![1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione](/CAS/20180713/GIF/830346-47-9.gif)
830346-47-9
185 suppliers
$24.00/100mg
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE](/CAS/GIF/239087-06-0.gif)
239087-06-0
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$14.00/100mg
![5-acetyl-4-hydroxy-2H-1,3-Thiazine-2,6(3H)-dione](/CAS/20180702/GIF/91114-97-5.gif)
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![1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione](/CAS/20180713/GIF/830346-47-9.gif)
830346-47-9
185 suppliers
$24.00/100mg