ChemicalBook CAS DataBase List 2-BENZYL-TETRAHYDROPYRROLO[3,4-C] PYRROLE-1,3(2H,3AH)-DIONE

2-BENZYL-TETRAHYDROPYRROLO[3,4-C] PYRROLE-1,3(2H,3AH)-DIONE synthesis

5synthesis methods

Product Name:2-BENZYL-TETRAHYDROPYRROLO[3,4-C] PYRROLE-1,3(2H,3AH)-DIONE
CAS Number:86732-32-3
Molecular formula:C13H14N2O2
Molecular Weight:230.26

2,5-Dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione

165893-99-2
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2-BENZYL-TETRAHYDROPYRROLO[3,4-C] PYRROLE-1,3(2H,3AH)-DIONE

86732-32-3
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$45.00/25mg

Yield:86732-32-3 90%

Reaction Conditions:

Stage #1: 2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dionewith carbonochloridic acid 1-chloro-ethyl ester in dichloromethane at 0; for 3 h;Heating / reflux;
Stage #2: with methanol for 3 h;Heating / reflux;

Steps:

1.2

1-Chloroethylchloroformate (3.24 mL) was added dropwise to a solution of compound 1 (5.22 g) in dichloromethane (75 mL) at 0 °C. The solution was then heated to reflux for 3 hours, cooled to room temperature and concentrated in vacuo. The residue was then dissolved in methanol (75 mL) and heated to reflux for another 3 hours. The mixture was cooled to 0 °C and ether (200 mL) was added. Filtration afforded the title compound 2 as a white solid (3. 38 g, 90%). LCMS: Rf: 0. 380 min, M+H+ : 231.

References:

WO2005/84667,2005,A1 Location in patent:Page/Page column 71

Pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-dione, 2,5-bis(phenylmethyl)-

86732-04-9
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86732-32-3
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86731-90-0 Synthesis

86731-90-0
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86732-32-3
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1H-Furo[3,4-c]pyrrole-1,3(5H)-dione, 5-(phenylmethyl)-

86731-92-2
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86732-32-3
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1H-Pyrrole-3-carboxylic acid, 1-(phenylmethyl)-4-[[(phenylmethyl)amino]carbonyl]-

86731-94-4
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86732-32-3
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References