2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in water;isopropyl alcohol at 60; for 1 h;

Steps:

4
Hydrochloric acid (20 ml) was added to a solution of 2-Isopropyl-4-(((N- methyl)amino)methyl thiazole (9.0 g) in isopropyl alcohol (90 ml) and the resultant mixture stirred at 60°C for 1 hour. The mixture was concentrated completely under reduced pressure and the residue dissolved again in isopropyl alcohol (90 ml) at about75⁰C. The solution was cooled to 20⁰C and the resulting slurry stirred at 2O⁰C for 4 hours and then at 0⁰C for 2 hours and filtered. The solid was washed with ethyl acetate twice (2 X 10 ml) and dried at 50⁰C under reduced pressure for 3 hours. Yield: 8.0 g HPLC purity: 99.50%

References:

RANBAXY LABORATORIES LIMITED WO2006/90270, 2006, A1 Location in patent:Page/Page column 9