ChemicalBook CAS DataBase List Benzyl 2-bromoethyl ether

Benzyl 2-bromoethyl ether synthesis

10synthesis methods

Product Name:Benzyl 2-bromoethyl ether
CAS Number:1462-37-9
Molecular formula:C9H11BrO
Molecular Weight:215.09

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Yield:1462-37-9 94.3%

Reaction Conditions:

with lithium bromide in acetonitrile at 70 - 80; for 2.5 h;Reagent/catalyst;Solvent;Temperature;

Steps:

3; 6; 9 Preparation of 2-benzyloxybromoethane

38.6 g of ethyl 2-benzyloxy p-toluenesulfonate (0.126 mol), 32.83 g of lithium bromide (0.378 mol) and 386 mL of acetonitrile were added to a 1000 mL four-necked flask, and the reaction was carried out at 70 ° C - 80 ° C for 2.5 h. The completion of the reaction was monitored by TLC, 300 mL of water was added, the reaction solution was extracted with 200 mL of chloroform three times, the organic phase was combined, washed once with 200 mL of water, and the organic phase was evaporated to give 25.6 g of colorless transparent oil, yield: 94.3%; HPLC purity: 99.9%. The GC purity was 99.9%.

References:

CN109896934,2019,A Location in patent:Paragraph 0041-0043; 0050-0052; 0059-0061

622-08-2 Synthesis