ChemicalBook CAS DataBase List Butyrophenone

Butyrophenone synthesis

13synthesis methods

Product Name:Butyrophenone
CAS Number:495-40-9
Molecular formula:C10H12O
Molecular Weight:148.2

622-76-4 Synthesis

622-76-4
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$29.80/5g

495-40-9
219 suppliers
$14.00/5g

Yield:495-40-9 93%

Reaction Conditions:

with water in neat (no solvent) at 100; for 22 h;Green chemistry;regioselective reaction;

Steps:

General procedure for hydration of alkynes
General procedure: Reactions were performed in a magnetically stirred round bot-tomed flask fitted with a condenser and placed in a temperature controlled oil bath. Zeolite (H) (100 mg) was added to the well stirred solution of alkyne (2 mmol) and H₂O (8 mmol) and the reac-tion mixture was allowed to stir at 100 °C. After disappearance of the alkyne (monitored by TLC) or after an appropriate time, the reaction mixture was cooled to room temperature, diluted with ethyl acetate. The catalyst was separated by filtration and the removal of solvent in vacuo yielded residue. and it was further puri-fied by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products were identified on the basisof H¹ and C¹³NMR spectral data.

References:

Mameda, Naresh;Peraka, Swamy;Marri, Mahender Reddy;Kodumuri, Srujana;Chevella, Durgaiah;Gutta, Naresh;Nama, Narender [Applied Catalysis A: General,2015,vol. 505,art. no. 15488,p. 213 - 216]

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109-74-0 Synthesis