ChemicalBook CAS DataBase List Clinafloxacin

Clinafloxacin synthesis

2synthesis methods

Product Name:Clinafloxacin
CAS Number:105956-97-6
Molecular formula:C17H17ClFN3O3
Molecular Weight:365.79

8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

101987-89-7
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105956-97-6
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: Et₃N / acetonitrile / 1.) reflux, 3 h, 2.) room temperature, 18 h
2: HCl, AcOH / 1.) 60 deg C, 4 h, 2.) room temperature, overnight

References:

Sanchez, Joseph P.;Domagala, John M.;Hagen, Susan E.;Heifetz, Carl L.;Hutt, Marland P.;et al. [Journal of Medicinal Chemistry,1988,vol. 31,p. 983 - 991]

FullText

A mixture of: (R)-7-[3-(tert-butoxycarbonylamino)pyrrolidin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid: (S)-7-[3-(tert-butoxycarbonylamino)pyrrolidin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

105956-96-5
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105956-97-6
161 suppliers
$77.00/50mg

References

Clinafloxacin Related Search:

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