ChemicalBook CAS DataBase List CYCLOPENTYL ISOTHIOCYANATE

CYCLOPENTYL ISOTHIOCYANATE synthesis

6synthesis methods

Product Name:CYCLOPENTYL ISOTHIOCYANATE
CAS Number:33522-03-1
Molecular formula:C6H9NS
Molecular Weight:127.21

463-71-8
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1003-03-8 Synthesis

1003-03-8
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33522-03-1
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$14.14/250mgs:

Yield:-

Reaction Conditions:

with calcium carbonate in dichloromethane;water at 20; for 2 h;

Steps:

Synthesis of Isothiocyanate 2 (General Procedure)
General procedure: To a mixture of a solution of amine 1 (23 mmol) in methylenechloride (20 mL) and calcium carbonate (CaCO₃) (138mmol) in water (80 mL) was added thiophosgene (45 mmol).The mixture was stirred for 2 h at room temperature, and then extracted with methylene chloride. The organic extract was washed with brine and dried over anhydrous MgSO₄.The solvent was removed by evaporation to afford 2 (55-94% yields).

References:

Nam, Kee Dal;Han, Minsoo;Yoon, Jun;Kim, Eun-A;Cho, Sung-Woo;Hahn, Hoh-Gyu [Bulletin of the Korean Chemical Society,2013,vol. 34,# 1,p. 271 - 274]