ChemicalBook CAS DataBase List Digitoxin

Digitoxin synthesis

3synthesis methods

Product Name:Digitoxin
CAS Number:71-63-6
Molecular formula:C41H64O13
Molecular Weight:764.94

5-Hexyne-2,3-diol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 2-benzoate, (2R,3R,4S)-

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71-63-6
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Yield:-

Steps:

Multi-step reaction with 12 steps
1: PPh₃; HBr / toluene / 6 h
2: 99 percent / DIBAL / CH₂Cl₂ / -78 °C
3: 96 percent / DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation
4: Bu₄NF / tetrahydrofuran
5: Et₃N; DMAP / CH₂Cl₂
6: 71 percent / PPh₃; HBr / toluene / 6 h
7: 98 percent / DIBAL / CH₂Cl₂ / -78 °C
8: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation
9: Et₃N; DMAP / CH₂Cl₂
10: PPh₃; HBr / CHCl₃
11: (NH₄)HF₂; N-methylpyrrolidine / dimethylformamide / 70 °C
12: NaOMe / methanol

References:

McDonald, Frank E.;Subba Reddy [Angewandte Chemie - International Edition,2001,vol. 40,# 19,p. 3653 - 3655]

FullText

D-ribo-Hex-1-enitol, 1,5-anhydro-2,6-dideoxy-3,4-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-

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71-63-6
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References

D-ribo-Hex-1-enitol, 1,5-anhydro-2,6-dideoxy-4-O-[2,6-dideoxy-3,4-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribo-hexopyranosyl]-3-O-[(1,1-dimethylethyl)dimethylsilyl]-

279684-92-3
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71-63-6
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$35.00/100mg

References

Digitoxin Related Search:

3-Hydroxysenkyunolide A