ChemicalBook CAS DataBase List Doxepin hydrochloride

Doxepin hydrochloride synthesis

13synthesis methods

Product Name:Doxepin hydrochloride
CAS Number:1229-29-4
Molecular formula:C19H22ClNO
Molecular Weight:315.84

87-41-2 Synthesis

87-41-2
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$6.00/10g

1229-29-4
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$16.00/1g

Yield:-

Steps:

Multi-step reaction with 7 steps
1: sodium methylate / ethanol / 4 h / 55 °C
2: aluminum (III) chloride / dimethyl sulfoxide / 8 h / 100 °C
3: magnesium; hydrogen; pyridine / 2 h / 38 °C / Reflux
4: sodium hydroxide / ethanol / 2 h / 70 °C
5: hydrogenchloride / water / 4 h / 50 °C
6: methyllithium / 5 h / 40 °C
7: hydrogenchloride / water / 20 h / 140 °C / 22502.3 - 30003 Torr

References:

Suzhou Yellow River Pharmaceutical Co., Ltd;Su, Zixuan;Qu, Xiaoming;Xiao, Zhua CN105418577, 2016, A