ChemicalBook CAS DataBase List Ellagic acid

Ellagic acid synthesis

7synthesis methods

Product Name:Ellagic acid
CAS Number:476-66-4
Molecular formula:C14H6O8
Molecular Weight:302.19

Ellagic acid is mainly extracted from plants, and it is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. Usually, the raw materials are degreasing and then extracted with an alkaline aqueous solution or extracted with ethanol. Then, after removing water-soluble proteins and gliadins, the sugar ligands can be decomposed by enzymes to obtain purer ellagic acid.

[1,1'-Biphenyl]-2,2'-dicarboxylic acid, 4,4',5,5',6,6'-hexahydroxy-, 2,2'-dimethyl ester

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Yield:476-66-4 100%

Reaction Conditions:

in methanol;water; for 24 h;Reflux;

Steps:

Ellagic acid (5)

Method 2: A solution of dicarboxylate 19 (72 mg, 0.19 mmol) was heated at reflux inmethanol/water (1:1, 3 mL) for 24 hours, then cooled to room temperature. The crude material wasextracted with n-butanol (3 × 10 mL) and the solvent evaporated in vacuo. Recrystallization of thecrude material with DMSO-chloroform (1:1) afforded the natural product 5 as a cream solid (58.7mg, 100%).

References:

Daley, Sharna-Kay;Downer-Riley, Nadale [Beilstein Journal of Organic Chemistry,2020,vol. 16,p. 2026 - 2031] Location in patent:supporting information

99-24-1 Synthesis