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ChemicalBook CAS DataBase List Esmolol

Esmolol synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: palladium(II) trifluoroacetate; Trimethylacetic acid; potassium carbonate / 120 °C / Schlenk technique; Inert atmosphere; Sealed tube
2.1: sulfuric acid / 10 h / Reflux; Inert atmosphere; Schlenk technique; Sealed tube
3.1: potassium carbonate / acetone / 5 h / 20 °C / Inert atmosphere; Schlenk technique; Sealed tube
3.2: 20 h / Reflux; Schlenk technique; Inert atmosphere; Sealed tube
4.1: methanol / 8 h / Reflux; Schlenk technique; Sealed tube; Inert atmosphere

References:

Wei, Yu;Tang, Huarong;Cong, Xuefeng;Rao, Bin;Wu, Chao;Zeng, Xiaoming [Organic Letters,2014,vol. 16,# 8,p. 2248 - 2251]

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