ChemicalBook CAS DataBase List Ethyl 3-amino-4-pyrazolecarboxylate

Ethyl 3-amino-4-pyrazolecarboxylate synthesis

7synthesis methods

Product Name:Ethyl 3-amino-4-pyrazolecarboxylate
CAS Number:6994-25-8
Molecular formula:C6H9N3O2
Molecular Weight:155.15

2-Pentenoic acid, 2-cyano-, ethyl ester, (2E)-

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Yield:6994-25-8 99%

Reaction Conditions:

with hydrazine in ethanol at 20;Reflux;

Steps:

To a stirred solution of ethyl (E)-2-cyano-3-ethoxyacrylate (5 g, 29.5 mmol) in ethanol (50 mL) wasadded hydrazine (1.8 mL, 29.5 mmol) dropwise. The mixture was stirred at room temperature for10 mins and was heated to reflux overnight. The solvent was removed in vacuo and the residue wasextracted with ethyl acetate, washed with H2O and brine. The water layer was extracted withethyl acetate for three times. The organic phase was dried over anhydrous sodium sulfate,filtered, and concentrated to afford compound 42a as light-yellow solid (4.54 g, 99%).

References:

Chen, Yun;Bai, Gang;Ning, Yi;Cai, Shi;Zhang, Tao;Song, Peiran;Zhou, Jinpei;Duan, Wenhu;Ding, Jian;Xie, Hua;Zhang, Huibin [European Journal of Medicinal Chemistry,2020,vol. 190,art. no. 112092] Location in patent:supporting information

94-05-3 Synthesis