ChemicalBook CAS DataBase List Ethyl 4-hydroxypiperidine-1-carboxylate

Ethyl 4-hydroxypiperidine-1-carboxylate synthesis

2synthesis methods

Product Name:Ethyl 4-hydroxypiperidine-1-carboxylate
CAS Number:65214-82-6
Molecular formula:C8H15NO3
Molecular Weight:173.21

Add triethylamine (1.5 equivalent) and ethyl chlorine 4-hydroxypiperidine-1-carboxylate (1.2 equivalent) to the dichloromethane solution of 4-hydroxypiperidine (1.0 equivalent) at 0 °C. Stir the mixture at 0 °C for 30 min. The reaction mixture is then poured into water and extracted with methylene chloride. Wash organic extracts with water and salt water. The compound is placed on sodium sulfate to dry. Finally, the organic extract is concentrated under reduced pressure to obtainEthyl 4-hydroxypiperidine-1-carboxylate.

5382-16-1
13 suppliers
$9.00/5G

541-41-3
6 suppliers
$21.00/5g

65214-82-6
284 suppliers
$10.00/5g

Yield:65214-82-6 84%

Reaction Conditions:

with triethylamine in dichloromethane at 0; for 0.5 h;

Steps:

6.4.2. General procedure for the preparation of carbamates 2a-e

General procedure: To a solution of 4-hydroxy piperidine (1.0 equivalent) in dichloromethane,triethylamine (1.5 equivalent) was added at 0 C followed bydropwise addition of chloroformates (methyl, ethyl, isobutyl andbenzyl) (1.2 equivalent). After stirring for 30 min at 0 C, the reactionmixture was poured into water and extracted with dichloromethane.The organic extracts were washed with water, brine and dried over sodiumsulfate. Then organic extract was concentrated under reducedpressure to yield product with quantitative yield.

References:

Pola, Suresh;Shah, Shailesh R.;Pingali, Harikishore;Zaware, Pandurang;Thube, Baban;Makadia, Pankaj;Patel, Hoshang;Bandyopadhyay, Debdutta;Rath, Akshyaya;Giri, Suresh;Patel, Jitendra H.;Ranvir;Sundar;Patel, Harilal;Kumar, Jeevan;Jain, Mukul R. [Bioorganic and Medicinal Chemistry,2021,vol. 35,art. no. 116071]

29976-53-2 Synthesis

29976-53-2
406 suppliers
$5.00/5g

65214-82-6
284 suppliers
$10.00/5g

References

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