ChemicalBook CAS DataBase List Ethyl 8-bromooctanoate

Ethyl 8-bromooctanoate synthesis

6synthesis methods

Product Name:Ethyl 8-bromooctanoate
CAS Number:29823-21-0
Molecular formula:C10H19BrO2
Molecular Weight:251.16

The synthesis method of ethyl 8-bromooctanoate: 1, 6-dibromohexane initial raw material is firstly used for carrying out substitution reaction with diethyl malonate to generate 2- (6-bromohexyl) diethyl malonate, and then ester hydrolysis and decarboxylation reaction are carried out to obtain the 8-bromooctanoic acid; and finally, esterification reaction is carried out to generate the compound 8-bromoethyl octanoate. synthesis of ethyl 8-bromooctanoate

64-17-5 Synthesis

64-17-5
699 suppliers
$10.00/50g

17696-11-6 Synthesis

17696-11-6
309 suppliers
$13.00/1g

29823-21-0
330 suppliers
$10.00/1g

Yield:29823-21-0 98%

Reaction Conditions:

with sulfuric acid for 3 h;Heating / reflux;

Steps:

21 Example 21; 8-Bromooctoanate (26)

To a solution of 8-bromooctanoic acid (5.0 g, 22 mmol) in ethanol (100 ML) was added H2SO4 (0.36 ML, 7.5 mmol) and the reaction was heated to reflux with stirring for 3 h.The crude reaction mixture was cooled to room temperature and washed H2O (100 ML), sat. NaHCO3 (2*100 ML), H2O (100 ML), dried MgSO4, and evaporated to dryness to afford a clear oil (5.5 g, 98% yield).

References:

US2003/228275,2003,A1 Location in patent:Page 42

17696-11-6 Synthesis

17696-11-6
309 suppliers
$13.00/1g

29823-21-0
330 suppliers
$10.00/1g

References

67-56-1 Synthesis