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FGH-10019 synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: copper(ll) bromide / chloroform; ethyl acetate / 3 h / 85 °C
2: ethanol / 80 °C
3: palladium on activated charcoal / methanol / 5 h / 20 °C / Inert atmosphere
4: triethylamine / chloroform / 3 h / 20 °C

References:

Bellale, Eknath;Naik, Maruti;Vb, Varun;Ambady, Anisha;Narayan, Ashwini;Ravishankar, Sudha;Ramachandran, Vasanthi;Kaur, Parvinder;McLaughlin, Robert;Whiteaker, James;Morayya, Sapna;Guptha, Supreeth;Sharma, Sreevalli;Raichurkar, Anandkumar;Awasthy, Disha;Achar, Vijayshree;Vachaspati, Prakash;Bandodkar, Balachandra;Panda, Manoranjan;Chatterji, Monalisa [Journal of Medicinal Chemistry,2014,vol. 57,# 15,p. 6572 - 6582]