FMOC-BETA-ALANINOL synthesis
- Product Name:FMOC-BETA-ALANINOL
- CAS Number:157887-82-6
- Molecular formula:C18H19NO3
- Molecular Weight:297.35
28920-43-6
523 suppliers
$5.00/5g
156-87-6
449 suppliers
$5.00/10g
157887-82-6
100 suppliers
$8.00/250mg
Yield: 99%
Reaction Conditions:
with triethylamine in 1,4-dioxane at 0 - 20; for 5 h;Inert atmosphere;
Steps:
1.3.22 Synthesis of compound 11
To 3-amino-1-propanol (13.31 mmol, 1.0 equiv.) dissolved in 1,4-dioxane (40 mL) wasadded triethylamine (13.31 mmol, 1.0 equiv.). The mixture was cooled down to 0°C in anice bath, before dropwise addition of FmocCl (13.31 mmol, 1.0 equiv.) in 1,4-dioxane (10mL). The reaction mixture was stirred at 0°C for 1 hour and then at room temperature for4 hours. The solvent was removed under reduced pressure. The product was purified onsilica gel with 0-100% EtOAc in hexanes.
References:
Guan, Jinming;Barnard, Leanne;Cresson, Jeanne;Hoegl, Annabelle;Chang, Justin H.;Strauss, Erick;Auclair, Karine [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 22,p. 5896 - 5902] Location in patent:supporting information
82911-69-1
599 suppliers
$7.00/25g
156-87-6
449 suppliers
$5.00/10g
157887-82-6
100 suppliers
$8.00/250mg
1001067-08-8
0 suppliers
inquiry
156-87-6
449 suppliers
$5.00/10g
157887-82-6
100 suppliers
$8.00/250mg