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ChemicalBook CAS DataBase List Furazolidone

Furazolidone synthesis

5synthesis methods
Furazolidone, 3-(5-nitrofurfuryliden)amino-2-oxazolidinone (33.7.8), is synthesized from 2-hydroazinoethanol, which is reacted with diethyloxalate to make 3- amino-2-oxazolidone. Reacting this with benzaldehyde gives the corresponding hydrazone (33.3.7). Purifying the resulting product and then reacting it with 5-nitrofurfurol gives furazolidone.

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: SOCl2; benzene
2: H2O; aqueous H2SO4

References:

Hayes et al. [Journal of the American Chemical Society,1955,vol. 77,p. 2282]

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