ChemicalBook CAS DataBase List Isolicoflavonol

Isolicoflavonol synthesis

7synthesis methods

Product Name:Isolicoflavonol
CAS Number:94805-83-1
Molecular formula:C20H18O6
Molecular Weight:354.35

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Yield:-

Steps:

Multi-step reaction with 11 steps
1.1: zinc(II) chloride; hydrogenchloride / diethyl ether / 6 h / Cooling with ice
2.1: potassium carbonate / acetone / 1.5 h / Reflux
3.1: potassium hydroxide / methanol / 96 h / 20 °C
4.1: iodine / dimethyl sulfoxide / 12.2 h / 110 °C
5.1: sodium carbonate; sodium hydrogencarbonate / acetone; dichloromethane; water / 0.25 h / Cooling with ice
5.2: 20 °C
6.1: potassium carbonate / acetone / 5 h / Inert atmosphere; Reflux
7.1: 5%-palladium/activated carbon / dichloromethane; methanol / 20 °C / Inert atmosphere
8.1: potassium iodide; potassium carbonate; copper(l) iodide / acetone / 48 h / Inert atmosphere; Reflux
9.1: 5%-palladium/activated carbon; quinoline / dichloromethane; methanol / 0.5 h / 20 °C / Inert atmosphere
10.1: 4 h / 170 °C / Inert atmosphere; Reflux
11.1: boron tribromide / pyridine / 12 h / -78 - 20 °C / Inert atmosphere
11.2: 1 h

References:

Suzhou Haofan Biological Co., Ltd.;Lu Xuegen;Gu Shousheng;Gu Gengfeng CN112047916, 2020, A