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ChemicalBook CAS DataBase List L-4'-TETRAHYDROPYRANYLGLYCINE

L-4'-TETRAHYDROPYRANYLGLYCINE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / -10 - 0 °C
1.2: 2 h / Reflux
1.3: 1 h / -30 - 20 °C
2.1: water; potassium hydroxide; dipotassium hydrogenphosphate / methanol / 1 h / 20 °C
3.1: sodium methylate / isopropyl alcohol / 0.08 h / Cooling with ice
4.1: formate dehydrogenase; nicotinamide adenine dinucleotide; ammonia; ammonium formate; leucine dehydrogenase / water / 30 °C / pH 8-8.5 / Enzymatic reaction

References:

ASYMCHEM LABORATORIES (TIANJIN) CO., LTD;ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD;TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD;ASYMCHEM LABORATORIES (FUXIN) CO., LTD;JILIN ASYMCHEM LABORATORIES CO., LTD.;Hong, Hao;Zheng, Changsheng;Guo, Lina US2016/319312, 2016, A1

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