ChemicalBook CAS DataBase List L-Glutamic acid 5-tert-butyl ester

L-Glutamic acid 5-tert-butyl ester synthesis

12synthesis methods

Product Name:L-Glutamic acid 5-tert-butyl ester
CAS Number:2419-56-9
Molecular formula:C9H17NO4
Molecular Weight:203.24

71989-18-9 Synthesis

71989-18-9
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2419-56-9
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Yield:-

Reaction Conditions:

with piperidine in N,N-dimethyl-formamide for 0.5 h;

Steps:

Fmoc-Glu(O-t-Bu)-OH (compound 19, 67mg, 0.156 mmol) was treated with piperidine (20%) in DMF (1 mL) for 30 min. The solvent was removed in vacuo to afford the crude primary amine. A solution of 4-carboxy-Pennsylvania Green succinimidyl ester3 (25 mg, 0.052 mmol) in DMF (1 mL) was added to the crude primary amine in DMF (1 mL) followed by DIEA (0.25 mL). The reaction was allowed to stir at 22 ⁰C for 16 h, dried in vacuo, and purified by flash column chromatography (MeOH, CH2C12, AcOH, 5:94.9:0.1) to afford compound 20 (27 mg, 90%) as an orange residue, mp 134- 138 ⁰C; IH NMR (400 MHz, CD3OD) δ 8.00 (s, IH), 7.94 (dd, J = 7.9, 1.2 Hz, IH), 7.40 (d, J = 7.9 Hz, IH), 6.98 - 6.89 (m, 2H), 6.81 - 6.77 (m, 2H), 4.70 (dd, J = 9.6, 4.9 Hz, IH), 2.47 (t, J = 7.0 Hz, 2H), 2.39 - 2.27 (m, IH), 2.14 - 2.08 (m, IH), 2.12 (s, 3H), 1.46 (s, 9H); 13C NMR (101 MHz, CD3OD) δ 174.95, 173.97, 169.66, 156.19, 138.02, 137.15, 136.55, 131.01, 130.47, 126.62, 112.98, 112.76, 106.32, 81.94, 53.70, 32.95, 28.35 (t), 27.66, 19.60 ; IR (film) v max 2929, 1678, 1607, 1536, 1371, 1302, 1190, 1139, 953, 842, 801, 750, 724 cm-1; HRMS (ESI+) m/z 568.1779 (M+H+, C30H27F2NO8, requires 568.1705).

References:

UNIVERSITY OF KANSAS;THE PENN STATE RESEARCH FOUNDATION;PETERSON, Blake R. WO2011/19942, 2011, A2 Location in patent:Page/Page column 31-32

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3886-08-6 Synthesis