Methyl 2-ethylisonicotinate synthesis

5synthesis methods

Product Name:Methyl 2-ethylisonicotinate
CAS Number:1531-16-4
Molecular formula:C9H11NO2
Molecular Weight:165.19

74-96-4 Synthesis

74-96-4
430 suppliers
$9.00/5g

58481-11-1 Synthesis

58481-11-1
182 suppliers
$6.00/1g

1531-16-4
7 suppliers
$540.00/1g

Yield:1531-16-4 63%

Reaction Conditions:

Stage #1: ethyl bromidewith magnesium in diethyl ether;Reflux;
Stage #2: methyl 2-chloroisonicotinatewith iron(III)-acetylacetonate in tetrahydrofuran;1-methyl-pyrrolidin-2-one;diethyl ether at 20; for 2 h;

References:

Whelligan, Daniel K.;Solanki, Savade;Taylor, Dawn;Thomson, Douglas W.;Cheung, Kwai-Ming J.;Boxall, Kathy;Mas-Droux, Corine;Barillari, Caterina;Burns, Samantha;Grummitt, Charles G.;Collins, Ian;Van Montfort, Rob L. M.;Aherne, G. Wynne;Bayliss, Richard;Hoelder, Swen [Journal of Medicinal Chemistry,2010,vol. 53,# 21,p. 7682 - 7698] Location in patent:supporting information; experimental part

58481-11-1 Synthesis

58481-11-1
182 suppliers
$6.00/1g

925-90-6 Synthesis

925-90-6
343 suppliers
$12.00/5ml

1531-16-4
7 suppliers
$540.00/1g

References

Hexanoic acid, 4-methylene-2-[(4-methylphenyl)sulfonyl]-2-(2-propen-1-yl)-, methyl ester

851762-26-0
0 suppliers
inquiry

1531-16-4
7 suppliers
$540.00/1g

References

2-Chloro-6-ethyl-isonicotinic acid methyl ester

4104-77-2
4 suppliers
inquiry

1531-16-4
7 suppliers
$540.00/1g

References

54881-18-4
6 suppliers
inquiry

1531-16-4
7 suppliers
$540.00/1g

References