ChemicalBook CAS DataBase List METHYL 3-IODO-4-METHOXYBENZOATE

METHYL 3-IODO-4-METHOXYBENZOATE synthesis

9synthesis methods

Product Name:METHYL 3-IODO-4-METHOXYBENZOATE
CAS Number:35387-93-0
Molecular formula:C9H9IO3
Molecular Weight:292.07

15126-06-4 Synthesis

15126-06-4
135 suppliers
$6.00/250mg

74-88-4
341 suppliers
$15.00/10g

35387-93-0
139 suppliers
$16.00/1g

Yield: 88.4%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 60; for 2 h;

Steps:

14.A Step A
Methyl 3-iodo-4-hydroxybenzoate (4.1 g, 14.75 mmol) was dissolved in DMF (25 mL). Potassium carbonate (2.65 g, 19.20 mmol) and methyl iodide (3.14 g, 22.12 mmol) were added. The resulting mixture was stirred at 60 ° C for 2 hours. Cooled to room temperature. Water (80 mL) was added. Extraction with ethyl acetate (40 mL x 3). The combined organic phases were washed successively with water (30 mL x 2) and saturated brine (20 mL). Dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The product was recrystallized from petroleum ether to give methyl 3-iodo-4-methoxybenzoate (37) (3.81 g). The yield was 88.4%.

References:

Atom Bioscience and Pharmaceutical Co., Ltd.;Shi, Dongfang;Fu, Changjin;Cheng, Xi CN106065010, 2016, A Location in patent:Paragraph 0134; 0135

121-98-2 Synthesis