ChemicalBook CAS DataBase List METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE synthesis

3synthesis methods

Product Name:METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
CAS Number:78471-43-9
Molecular formula:C9H8Br2O2
Molecular Weight:307.97

Methyl 4-bromo-2-bromomethyl-benzoate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research. It can be synthesized by halogenation and esterification of 4-Bromo-2-methylbenzoic acid.

99548-55-7 Synthesis

BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER

99548-55-7
160 suppliers
$6.00/1g

78471-43-9
216 suppliers
$6.00/250mg

Yield:78471-43-9 97%

Reaction Conditions:

with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane at 85; for 2 h;

Steps:

1 Methyl 4-bromo-2-(bromomethyl)benzoate
A mixture of methyl 4-bromo-2-methylbenzoate (1 g, 4.4 mmol), NBS (0.80 g, 4.4 mmol), BPO (56 mg, 0.23 mmol), and CCl₄ (20 mL) was stirred at 85 °C for 2 hours. The mixture was filtered with a pad of silica gel and concentrated to afford the desired product (1.3 g, 97% yield).

References:

ARAXES PHARMA LLC;WU, Tao;WANG, Yi;LI, Liansheng;FENG, Jun;LIU, Yuan;REN, Pingda;LIU, Yi WO2018/68017, 2018, A1 Location in patent:Page/Page column 126

FullText

68837-59-2 Synthesis

68837-59-2
331 suppliers
$5.00/1g

78471-43-9
216 suppliers
$6.00/250mg

References

99548-55-7 Synthesis

99548-55-7
160 suppliers
$6.00/1g

7440-33-7 Synthesis

7440-33-7
275 suppliers
$22.00/50g

78471-43-9
216 suppliers
$6.00/250mg

References

METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE Related Search:

2-(Bromomethyl)benzoic acid BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER 2-(BROMOMETHYL)BENZYL ALCOHOL, 95%