Methyl L-leucinate hydrochloride synthesis
- Product Name:Methyl L-leucinate hydrochloride
- CAS Number:7517-19-3
- Molecular formula:C7H16ClNO2
- Molecular Weight:181.66
61-90-5
774 suppliers
$10.00/25G
7517-19-3
337 suppliers
$5.00/5g
Yield:7517-19-3 98%
Reaction Conditions:
with thionyl chloride in methanol
Steps:
179.1 Trans-4-Acetylthio-5-isobutyl-1-(4-phenoxybenzyl)pyrrolidin-2-one
(1) Similarly to Example 20 and starting from 6.56 g (50.0 mmol) of D,L-leucine, 50 ml of methanol and 13.0 ml (180 mmol) of thionyl chloride, 8.93 g (yield: 98%) of D,L-leucine methyl ester hydrochloride was obtained as a white powder. 1H-NMR (300 MHz, D2O); δ: 4.17 (1H, t, J=6.8 Hz), 3.87 (3H, s), 1.90 (1H, m), 1.78 (2H, m), 00 (3H, d, J=6.0 Hz), 0.99 (3H, d, J=6.0 Hz).
References:
Takeda Chemical Industries, Ltd. US6420415, 2002, B1
67-56-1
734 suppliers
$7.29/5ml-f
760-84-9
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$63.20/5ml-f
7517-19-3
337 suppliers
$5.00/5g
67-56-1
734 suppliers
$7.29/5ml-f
13139-15-6
425 suppliers
$7.00/5g
7517-19-3
337 suppliers
$5.00/5g
