ChemicalBook CAS DataBase List N-Boc-piperidine-3-methanol

N-Boc-piperidine-3-methanol synthesis

6synthesis methods

Product Name:N-Boc-piperidine-3-methanol
CAS Number:116574-71-1
Molecular formula:C11H21NO3
Molecular Weight:215.29

4606-65-9 Synthesis

4606-65-9
249 suppliers
$9.00/1g

24424-99-5 Synthesis

24424-99-5
816 suppliers
$13.50/25G

121-44-8 Synthesis

121-44-8
832 suppliers
$9.00/5g

116574-71-1
290 suppliers
$8.00/5g

Yield:116574-71-1 96%

Reaction Conditions:

in dichloromethane

Steps:

31.A A.
A. N-Boc-3-hydroxymethylpiperidine To a stirred solution of 3-hydroxymethylpiperidine (15.1 g, 131 mmol) and Et₃ N (21.9 mL, 158 mmol) in 100 mL of dichloromethane was added dropwise a solution of di-t-butyl dicarbonate (31.5 g, 144 mmol) in 100 mL of dichloromethane over 1 h. The reaction was stirred at room temperature for 18 h and then diluted with 200 mL of dichloromethane. The resulting solution was washed with 1N HCl solution (3*100 mL), saturated NaHCO₃ solution (2*100 mL) and brine (1*100 mL). The organic layer was dried (MgSO₄), filtered and concentrated in vacuo to give N-Boc-3-hydroxymethylpiperidine (27.0 g, 96%).

References:

Bristol-Myers Squibb Company US5583146, 1996, A

FullText

4606-65-9 Synthesis

4606-65-9
249 suppliers
$9.00/1g

24424-99-5 Synthesis

24424-99-5
816 suppliers
$13.50/25G

116574-71-1
290 suppliers
$8.00/5g

References