N-(ETHOXYCARBONYL)THIOPROPIONAMIDE synthesis
- Product Name:N-(ETHOXYCARBONYL)THIOPROPIONAMIDE
- CAS Number:59812-12-3
- Molecular formula:C6H11NO2S
- Molecular Weight:161.22
2386-64-3
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$45.00/5ml
16182-04-0
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$10.00/1g
59812-12-3
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$280.00/1g
Yield:59812-12-3 47 %
Reaction Conditions:
in tetrahydrofuran at -78 - 20;
Steps:
5.A Step A: Synthesis of ethyl ethylcarbothioylcarbamate
At -78°C, ethylmagnesium chloride(9.1 ml, 2.0 mol/L, 18.2 mmol) was added to tetrahydrofuran (20.0 ml) containing ethoxycarbonyl isothiocyanate (2.0 g, 15.2 mmol),After the dropwise addition, the reaction system was slowly raised to room temperature and reacted for 1.0 hour.After the reaction was completed, quenched with water, the mixture was extracted with ethyl acetate (50 ml × 2 times), the organic phases were combined, and the organic phase was washed with saturated ammonium chloride solution (50 ml × 2 times), and then washed with anhydrous sodium sulfate Dry and finally concentrate under reduced pressure.1.16 g of ethyl ethylcarbothioylcarbamate was obtained as a pale yellow oil (yield: 47%).
References:
CN115745983,2023,A Location in patent:Paragraph 0140-0147
925-90-6
343 suppliers
$12.00/5ml
16182-04-0
209 suppliers
$10.00/1g
59812-12-3
20 suppliers
$280.00/1g