N-(Phosphonomethyl)glycine 2-propylamine (1:1) synthesis

Yield:-

Reaction Conditions:

in water; pH=4.5 - 4.7 at 0 - 55;Product distribution / selectivity;

Steps:

1; 3.1
Example 1 - Preparation of Glyphosate compositionsThe glyphosate compositions below are prepared according to the following procedure: Procedure:1 ) mixing the water of surfactant system 1. A slurry is obtained2) add 50% of glyphosate compound and neutralize with a molar equivalent of isopropylamine, to obtain that comprise 50% of the final amount of the isopropylammonium salt3) add the remaining 50% of glyphosate compound and neutralize with a molar equivalent of isopropylamine.4) add the additive compoundThe viscosity of the composition is measured at 25°C, with a RVT BrookfieldViscosimeter, Spindle No. 2, at 10 rpm.Crystallization is evaluated after 1 week at room temperature ("RT").; Procedure:; Step 1 ) Preparation of the Glyphosate-lsopropylamine salt solution; 1 a) GIy-IPA solution is prepared in 2 steps. To 80% of the water, Vi of Glyphosate Acid powder tech. (95% min. purity) is added to form the slurry. The mixture is aminated gradually, with Vi of 100% lsopropylamine, which is pre-cooled to 0⁰C. The reaction temperature is maintained at approximately 55°C.1 b) The remaining Vi Glyphosate Acid technical is added and aminated with the remaining Vi of lsopropylamine. The pH of 7% w/w solution is checked to confirm value within 4.5 - 4.71 c) Extra IPA, approx.12%, is needed to fall within the rquired pH value. This is subtracted from the remaining 20% water and the remaing water added.

References:

RHODIA OPERATIONS WO2009/60026, 2009, A2 Location in patent:Page/Page column 20-22

FullText