NALBUPHINE HYDROCHLORIDE synthesis
- Product Name:NALBUPHINE HYDROCHLORIDE
- CAS Number:23277-43-2
- Molecular formula:C21H28ClNO4
- Molecular Weight:393.91
20594-83-6
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Yield: 89%
Reaction Conditions:
with hydrogenchloride in ethanol;water; pH=4 - 4.5 at 50;
Steps:
1
Nalbuphine alkaloid (33.1g) was charged to a flask containing ethanol (79ml ) and water (20 ml) and the mixture heated to 500C. Concentrated Hydrochloric acid (9.1 mis) was added to adjust to within the pH range 4 - 4.5. The resulting solution was cooled to <10°C using an ice bath and held for ~ 2 hours and filtered. The Nalbuphine hydrochloride solid was washed with ethanol:water (10.6ml:2.6ml) and dried at 55°C in a fan oven to afford 35.27 g (89 % theory) of Nalbuphine hydrochloride.
References:
JOHNSON MATTHEY PUBLIC LIMITED COMPANY;WILSON, George Scott;YOUNG, Maureen Joan WO2011/21029, 2011, A1 Location in patent:Page/Page column 4
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52446-24-9
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$690.00/250 mg
23277-43-2
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