ChemicalBook CAS DataBase List P-TOLYL DISULFIDE

P-TOLYL DISULFIDE synthesis

12synthesis methods

Product Name:P-TOLYL DISULFIDE
CAS Number:103-19-5
Molecular formula:C14H14S2
Molecular Weight:246.39

1576-35-8 Synthesis

1576-35-8
441 suppliers
$10.00/1g

103-19-5
148 suppliers
$19.00/5g

Yield:103-19-5 100%

Reaction Conditions:

with 1,10-Phenanthroline;oxygen;manganese triacetate;lithium bromide in dimethyl sulfoxide at 80; under 760.051 Torr; for 12 h;Green chemistry;chemoselective reaction;

Steps:

15 4.2 General procedure for the synthesis of C3-thioether indoles 3
General procedure: A mixture of alkynes 1 (0.5mmol), 2 (0.6mmol), Mn(OAc)₃ (23mg, 20mol%), LiBr (10mol%), 1,10-phen (10mol%) in DMSO under 1atm oxygen atmosphere in a test tube (15mL) equipped with a magnetic stirring bar. The mixture was stirred at 80°C for given time. After the reaction was completed, 10mL ethyl acetate (3×10mL) was added into the tube. The combined organic layers were washed with brine to neutral, dried over MgSO₄, and concentrated in vacuum. Purification of the residue on a preparative TLC afforded the desired products.

References:

He, Lin;Li, Xianwei [Tetrahedron,2017,vol. 73,# 43,p. 6138 - 6145] Location in patent:supporting information

624-31-7 Synthesis