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penphenone synthesis

3synthesis methods
-

Yield:-

Reaction Conditions:

Stage #1:phenylacetic acid with isopropylmagnesium chloride in tetrahydrofuran at 40; for 1 h;
Stage #2:butanone in tetrahydrofuran at 25 - 40; for 1 h;

References:

Fei, Haiyang;Fu, Yao;Jalani, Hitesh B.;Li, Guigen;Lu, Hongjian;Wu, Hongmiao;Xu, Zheyuan;Zhu, Lin [Organic Letters,2020] Location in patent:supporting information