ChemicalBook CAS DataBase List Propiconazole

Propiconazole synthesis

5synthesis methods

Product Name:Propiconazole
CAS Number:60207-90-1
Molecular formula:C15H17Cl2N3O2
Molecular Weight:342.22

5343-92-0
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1-(2,4-DICHLOROLPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE

58905-16-1
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60207-90-1
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$28.00/100mg

Yield:60207-90-1 98.9%

Reaction Conditions:

with toluene-4-sulfonic acid in cyclohexane; for 8 h;Reflux;

Steps:

1.2 2) Synthesis of 1-[2-(2,4-Dichlorophenyl)-4-propyl-1,3-dioxolane-2-methyl]-1hydro-1,2,4triazole :

Add 125g of (2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone obtained in the previous step into the four-neck flask,Then add 500g of cyclohexane,Catalyst p-toluenesulfonic acid,65g of 1,2-pentanediol,Warm up to reflux,Reflux for 8h,After the response is qualified,Add 300g of water to the reaction for washing,Stratification,Oil phase negative pressure desolventizing,Obtain 1-[2-(2,4-Dichlorophenyl)-4-propyl-1,3-dioxolane-2-methyl]-1hydro-1,2,4triazole or propane Azole 163.6g,The content is 99.2%,The yield was 98.9%.

References:

CN113336715,2021,A Location in patent:Paragraph 0020; 0022