ChemicalBook CAS DataBase List Propofol

Propofol synthesis

8synthesis methods

Product Name:Propofol
CAS Number:2078-54-8
Molecular formula:C12H18O
Molecular Weight:178.27

13423-73-9 Synthesis

13423-73-9
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$26.00/100mg

2078-54-8
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$26.78/25g

Yield:2078-54-8 93.5%

Reaction Conditions:

Stage #1: 4-hydroxy-3,5-diisopropylbenzoic acid;sodium hydroxide in ethylene glycol at 140 - 145; for 7 h;Inert atmosphere;
Stage #2: with hydrogenchloride in lithium hydroxide monohydrate;ethylene glycol; pH=1 - 2; for 1 h;

Steps:

2

Example 2:To the solution of 4-hydroxy-3,5-diisopropyl benzoic acid lOOg (0.45 M) (example 1) in ethylene glycol (150 ml) was added sodium hydroxide pallets 41.5g (1.03M) and heated to 140- 145 °C under inert atmosphere. After 7 hrs of continued heating at 140-145°C, the react4on mass was cooled to room temperature and diluted with 5 times water. The pH of the mass was then adjusted to 1-2 using concentrated Hydrochloric acid, reaction mixtiire was stirred for one hour and extracted three times with 200 ml toluene, combined toluene layers were washed twice with 5 % aq. sodium bicarbonate solution (50 ml) and finally with water (200 ml), solvent was removed under reduced pressure and a dark brown colored residue which remained was distilled under high vacuum condition (0.2 mm/Hg) to yield 75g ( 93.5%) of 2,6- diisopropyl phenol collected as a colourless to pale yellow oily liquid, HPLC Purity 99.93 %.

References:

WO2011/161687,2011,A1 Location in patent:Page/Page column 8-9