ChemicalBook CAS DataBase List PYRETHRIN 2

PYRETHRIN 2 synthesis

5synthesis methods

Product Name:PYRETHRIN 2
CAS Number:121-29-9
Molecular formula:C22H28O5
Molecular Weight:372.45

97-41-6
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$10.00/5g

121-29-9
80 suppliers
$120.00/1g

Yield:-

Steps:

Multi-step reaction with 9 steps
1.1: sodium hydride / mineral oil / 3 h / Inert atmosphere
2.1: potassium hydroxide / ethanol; water / 3 h
3.1: (S)-1-(1-Naphthyl)ethylamine / ethanol / 3 h / 20 °C
4.1: ozone / Acidic conditions
5.1: pyrrolidine / 1 h / 60 °C
6.1: potassium hydroxide / water; methanol; 5,5-dimethyl-1,3-cyclohexadiene / 16 h / 20 - 25 °C / Inert atmosphere
7.1: 1-methyl-1H-imidazole; p-toluenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 0 - 5 °C / Inert atmosphere
7.2: 2 h / 20 - 25 °C / Inert atmosphere
8.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 5 h / 20 - 25 °C
9.1: potassium carbonate / hexane; toluene; methanol / 16 h / 20 - 25 °C / Inert atmosphere

References:

Ashida, Yuichiro;Kawamoto, Momoyo;Matsuo, Noritada;Moriyama, Mizuki;Tanabe, Yoo [Journal of Organic Chemistry,2020,vol. 85,# 5,p. 2984 - 2999]