(R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE synthesis
- Product Name:(R)-1-BOC-3-DIMETHYLAMINOPYRROLIDINE
- CAS Number:1004538-33-3
- Molecular formula:C11H22N2O2
- Molecular Weight:214.3
1004538-32-2
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1004538-33-3
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Yield: 95%
Reaction Conditions:
with sodium hydroxide;water in toluene
Steps:
9-2
Step 9-2: Production of (R)-1-(tert-butoxycarbonyl)-3-dimethylaminopyrrolidine To 1.25 g of (R)-1-(tert-butoxycarbonyl)-3-dimethylaminopyrrolidine hydrochloric acid salt (chemical purity: 99.9 area%) obtained in the step 9-1 were added 2.46 g of a 23% by weight brine, 5.03 g of toluene and 738 mg of a 30% by weight aqueous sodium hydroxide solution, and the mixture was stirred. After conducting liquid separation, the organic layer was concentrated. Then vacuum drying was carried out to give the title compound as 999 mg of a colorless and transparent liquid (chemical purity: 99.5 area%, yield 95%). 1H-NMR (CDCl3): d (ppm) 1.46 (s, 9H), 1.74 (m, 1H), 2.05 (m, 1H), 2.24 (s, 6H), 2.63 (m, 1H), 3.05 (m, 1H), 3.27 (m, 1H), 3.45-3.69 (m, 2H)
References:
Kaneka Corporation EP2050735, 2009, A1 Location in patent:Page/Page column 21-22
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147081-49-0
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1004538-33-3
28 suppliers
$45.00/10mg