ChemicalBook CAS DataBase List (R)-(+)-2-Chloropropionic acid

(R)-(+)-2-Chloropropionic acid synthesis

6synthesis methods

Product Name:(R)-(+)-2-Chloropropionic acid
CAS Number:7474-05-7
Molecular formula:C3H5ClO2
Molecular Weight:108.52

338-69-2 Synthesis

338-69-2
589 suppliers
$5.00/10g

7474-05-7
196 suppliers
$11.00/1g

Yield:7474-05-7 93.4%

Reaction Conditions:

with hydrogenchloride;sodium nitrate in water at -5 - 25; for 0.111167 h;

Steps:

18 Example 18
Hydrochloric acid (25 mL, 7.5 mol/L) was added to a beaker and cooled to -5 to 0°C.Alanine (3.3409 g, 0.0375 mol) was weighed and dissolved in the hydrochloric acid to obtain a homogeneous mixed solution and transferred to a syringe matched with the injection pump A at a flow rate of 1 mL/min.An aqueous solution (40%) of sodium nitrite (5.1735 g, 0.075 mol) was transferred to a syringe fitted with a syringe pump B at a flow rate of 0.5 mL/min.The two were mixed with a Y-type mixing valve and pumped together into a microreactor. The volume of the microreactor was 10 mL, the reaction temperature was 25° C., and the reaction time was 6.67 min. The reaction solution was α-chlorocarboxylic acid product.The resulting product was examined by liquid chromatography-mass spectrometry and had a HRMS (TOF) m/z [M-H]- of 120.9933 and a yield of 93.4%.

References:

China Pharmaceutical University;Yang Zhao;Wang Zhixiang;Fang Zheng;Guo Kai CN107879927, 2018, A Location in patent:Paragraph 0060; 0061

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