SARCOSINE HYDROCHLORIDE synthesis

Yield: 63%

Reaction Conditions:

Stage #1:chloroacetic acid;methylamine with sodium hydrogencarbonate in water for 0.5 h;
Stage #2: with hydrogenchloride in water; pH=2 at 35; for 24 h;

Steps:

1 General procedure for preparation of ligands
General procedure: Sodium bicarbonate, NaHCO3, (8.41 g, 100 mmol) was slowlyadded with continuous stirring to a solution of chloroacetic acid(9.45 g, 100 mmol) in distilled water (30 ml). A solution of eachamine (100 mmol) in distilled water (5 ml) was added dropwisewith constant stirring to the solution obtained in the previous step.After half an hour, NaHCO3 (8.41 g, 100 mmol) was added againand stirred with a magnetic stirrer. Then, this solution was acidifiedwith HCl to pH 2 and slowly evaporated at 35 C until crystalsappeared and left aside for 24 h. Recrystallization was carried outby dissolving the filtered crystals in the minimum amount of distilledwater, acidifying to pH 2, and slow evaporation. The purecrystal obtained was filtered and dried in a vacuum oven at 35 C.

References:

Ajloo, Davood;Eslami Moghadam, Mahboube;Ghadimi, Khadijeh;Ghadamgahi, Maryam;Saboury, Ali Akbar;Divsalar, Adeleh;Sheikhmohammadi, Minoo;Yousefi, Khalil [Inorganica Chimica Acta,2015,vol. 430,p. 144 - 160]