ChemicalBook CAS DataBase List Triclopyr

Triclopyr synthesis

6synthesis methods

Product Name:Triclopyr
CAS Number:55335-06-3
Molecular formula:C7H4Cl3NO3
Molecular Weight:256.47

TRICLOPYR METHYL ESTERSUFFIX ADDED TO CAS TO DIFFERENTIATE FROM NON-DEUTERATED/DERIVATIZED COMPOUND.

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Yield:55335-06-3 94.2%

Reaction Conditions:

Stage #1:methyl 2-[(3,5,6-trichloropyridin-2-yl)oxy]acetate with water;sodium hydroxide at 80 - 85; for 4 h;
Stage #2: with sulfuric acid in water; pH=1 - 2Product distribution / selectivity;

Steps:

4
In a reactor equipped with a mechanical stirrer, thermometer pocket and reflux condenser, 0.351 moles of triclopyr-methyl ester was taken. Water was added to make 10% aqueous slurry. 16.85 g (0.421 moles) of NaOH was added. The slurry was heated to 80-85⁰C for four hours. The reaction mass was then cooled to room temperature. 70 ml H2O2 was added and mixture was stirred for 30 min. The reaction mass was then acidified to pH 1-2 with sulfuric acid to get white precipitate which was filtered and dried to obtain product in 94.2% yield

References:

EXCEL CROP CARE LIMITED;C C SHROFF RESEARCH INSTITUTE;AIMCO PESTICIDES LIMITED;SHROFF, Dipesh, Kantisen;SHROFF, Ashwin, Champraj;DAVE, Samir, Pradip WO2010/23679, 2010, A2 Location in patent:Page/Page column 6-7

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