Inhibitor refers to substance that can hinder the chemical reactions, biological reactions (including immune response) and biological activity. In present time, commonly used inhibitors include immunosuppressants and inhibitors. 1. Immunosuppressive agents: immunosuppressants system refers to drug that can reduce the immune response. It can selectively suppress certain steps of the immune response and immune cells. Immune response refers to the body’s response to a variety of pathogenic substances. Some reactions are favorable to the body and can enhance the body's resistance to disease; some have adverse effects on the body and can cause tissue damage or disorders of physiological functions (allergy). Therefore, patients suffering from allergic reactions being harmful to the body should be subject to the treatment of immunosuppressant to affect the related immune processes and reduce the immune response of the body. For the treatment of various autoimmune diseases and weakening the tissue incompatibility, it has been developed of a variety of immunosuppressive agents, some of which have been widely used in clinical practice. Commonly used immunosuppressants include glucocorticoids (prednisone, prednisolone, etc.), alkylating agents (nitric oxide mustard, cyclophosphamide, thiotepa, busulfan, etc.), and antimetabolites (6- mercaptopurine, azathioprine, methotrexate, etc.). The mechanism of immunosuppressants, though not entirely clear, but is characterized by the following several aspects: ① most kinds of immunosuppressants can simultaneously inhibit cellular and humoral immunity and can be used for organ transplantation and autoimmune disease. ②Its inhibitory effect is strong for the primary immune response while the inhibitory effect against secondary response is weak. ③It can simultaneously act on normal and pathological immunity, therefore, can often lead to some complications. ④These drugs often have strong with serious adverse reactions. 2. Enzyme
Synthesis of Ozanimod Hydrochloride
Ozanimod Hydrochloride is prepared from the eastern fragment joined to the western fragment to form a central oxadiazole ring and through a chemical reaction.
Dec 28，2023 Inhibitors
A BRAF inhibitor: Encorafenib (LGX818)
Encorafenib (LGX818) is a BRAF inhibitor, and detection of a BRAF V600E or BRAF V600K mutation in tumor specimens is required before treatment.
Dec 27，2023 Inhibitors
A small-molecule inhibitor: IPI 145(Duvelisib)
Duvelisib (IPI 145) is a small-molecule inhibitor of phosphatidylinositol-3 kinase that has been developed as an oral treatment for various cancer indications.
Dec 27，2023 Inhibitors
How to synthesize Dacomitinib (PF299804)?
Dacomitinib (PF299804), developed by Pfizer, is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.
Dec 27，2023 Inhibitors
The synthesis method of Binimetinib
Binimetinib is a non-ATP competitive mitogen-activated protein kinase 1/2 (MEK1/2) inhibitor discovered by Array BioPharma.
Dec 27，2023 Inhibitors
Osilodrostat Phosphate: Synthesis and Introduction
Osilodrostat Phosphate (LCI 699) is prepared using imidazole salt as raw material and by reduction, alkylation, saponification and other reactions.
Dec 27，2023 Inhibitors
How is Filgotinib synthesised?
Filgotinib is prepared using 2-aminopyridine as raw material by condensation, cyclisation, coupling and other reactions.
Dec 27，2023 Inhibitors
What is Apalutamide
Apalutamide is a next-generation oral androgen receptor (AR) inhibitor that Janssen is developing for the treatment of prostate cancer.
Dec 26，2023 Inhibitors
A cinacalcet analog-Evocalcet
Evocalcet, a novel oral calcimimetic agent, is an allosteric modulator that acts on the calcium-sensing receptors on the membrane of parathyroid cells to suppress parathyroid hormone (PTH) secretion.
Dec 26，2023 Inhibitors
Synthesis of Delgocitinib
Delgocitinib is synthesised using bromolactone as raw material by chemical reaction.
Dec 26，2023 Inhibitors