| Identification | Back Directory | [Name]
2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide | [CAS]
100130-32-3 | [Synonyms]
VUF8430 hydrobromide
VUF 8430 dihydrobromide >=97% (NMR)
2-guanidinoethyl carbamimidothioate dihydrobromide
2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester
2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide | [Molecular Formula]
C4H13Br2N5S | [MDL Number]
MFCD01694605 | [MOL File]
100130-32-3.mol |
| Hazard Information | Back Directory | [Description]
VUF8430 is a histamine H4 receptor agonist (Ki = 31.6 nM). It is selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 μM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8). VUF8430 inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC50 = 50.1 nM). In vivo, VUF8430 (30 mg/kg) enhances HCl-induced formation of gastric lesions in rats. It also reduces mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI). | [Uses]
VUF 8430 Dihydrobromide is an H4 receptor agonist. | [storage]
Desiccate at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|