| Identification | Back Directory | [Name]
Cibenzoline succinate | [CAS]
100678-32-8 | [Synonyms]
ole(1:1)
ritmalan
cipralan
Cinobezile
ro22-7796/001
Cibenzoline succinate
cibenzolinesuccinate(1:1)
(+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1)
4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolsuccinate
4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolesuccinate
2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
butanedioicacid,compd.with2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidaz
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazol(+-)-1h-imidazolbutanedioate(
butanedioicacid,compd.with2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole(1:1)
succinic acid, compound with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2)
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor | [EINECS(EC#)]
634-471-4 | [Molecular Formula]
C22H24N2O4 | [MDL Number]
MFCD00941423 | [MOL File]
100678-32-8.mol | [Molecular Weight]
380.44 |
| Chemical Properties | Back Directory | [Melting point ]
165° | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥5mg/mL | [form ]
solid | [color ]
white to off-white | [Water Solubility ]
H2O: ≥5mg/mL | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
Cardiac
depressant (anti-arrhythmic). | [Uses]
Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent. | [Definition]
ChEBI: Cibenzoline succinate is a diarylmethane. | [General Description]
Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient. | [Biochem/physiol Actions]
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells. |
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