| Identification | Back Directory | [Name]
Largazole | [CAS]
1009815-87-5 | [Synonyms]
Largazole
(+)-largazole
AXESYCSCGBQJBL-SZPBEECKSA-N
Octanethioic acid, S-[(3E)-4-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.12,5]eicosa-2(20),16(19),18-trien-11-yl]-3-buten-1-yl] ester | [Molecular Formula]
C29H42N4O5S3 | [MDL Number]
MFCD18074512 | [MOL File]
1009815-87-5.mol | [Molecular Weight]
622.86 |
| Hazard Information | Back Directory | [Uses]
Largazole is a potent and selective histone deacetylase (HDAC) inhibitor. | [Uses]
Largazole is derived from cyanobacteria that grow on coral reefs, which may have potentials as an anti-cancer drug. Largazole is a potent histone deacetylase inhibitor. [1] Largazole has its potent antiproliferative activity against a number of cancer cell-lines including MDA-MB-231 mammary cells (GI50 7.7 nM), U2OS fibroblastic osteosarcoma cells (GI50 55 nM), HT29 colon cells (GI50 12 nM), and IMR-32 neuroblastoma cells (GI50 16 nM). |
|
|